Gabriel phthalimide synthesis (primary amines) (Phthalimide anion alkylates then releases 1° aliphatic amine (excellent for 1° amines))
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Phthalimide anion alkylates then releases 1° aliphatic amine (excellent for 1° amines)
What each symbol means
| Symbol | What it stands for |
|---|---|
| R-X | Typically primary alkyl halide |
| Hydrazine | Ing–Manske deprotection (common pathway) |
When to use this
Two-step alkylation + cleavage; avoids polyalkylation of ammonia; works best for primary alkyl halides (SN2).