Therapeutic index (drug safety margin, JEE-style definition) (TI = LD50 / ED50 (higher → wider safety window in animal models))
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TI = LD50 / ED50 (higher → wider safety window in animal models)
What each symbol means
| Symbol | What it stands for |
|---|---|
| ED50 | Median effective dose |
| LD50 | Median lethal dose |
When to use this
Animal toxicity screens; higher TI generally indicates safer therapeutic window (simplified teaching definition).